Peer-reviewed veterinary case report
Toxicity of low-dose half-body radiation and chemo in dogs
By Lurie, D M et al.·Published in Veterinary and comparative oncology·2008·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A toxicity study of low-dose rate half-body irradiation and chemotherapy in dogs with lymphoma.
- Species:
- dog
Plain-English summary
Thirteen dogs with lymphoma were treated with a combination of low-dose radiation and chemotherapy to see how well they would respond. While most dogs tolerated the treatment, some experienced mild to moderate side effects like decreased appetite and gastrointestinal issues, especially those receiving a higher dose of radiation. One dog sadly passed away due to complications from the treatment. Overall, the results were promising, suggesting that this treatment approach could be effective for dogs with lymphoma, especially at the lower radiation dose.
People also search for: dog lymphoma treatment options · side effects of radiation in dogs · chemotherapy for dogs with cancer
Abstract
Thirteen dogs with previously untreated multicentric lymphoma were enrolled in a prospective study investigating the effects of low-dose rate total body irradiation (TBI) and chemotherapy. Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderate haematological and gastrointestinal (GI) signs. One dog died from treatment complications. Anorexia was noted independent of dose. Haematological toxicity was more common and more severe after 8 Gy treatment. GI toxicity was more likely postcaudal half-body irradiation with 8 Gy. Other than leukotrichia, late effects from radiation were not observed. Results indicated that haematological and nonhaematological toxicity was dose dependent. However, the protocol was well tolerated and treatment intensification using a 2-week inter-radiation interval was possible in all dogs treated with 6 Gy. Preliminary survival data for these dogs were very encouraging, providing a strong rationale to analyse the efficacy of low-dose rate irradiation (LDRI) in canine lymphoma.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19178684/