Peer-reviewed veterinary case report
Abnormal sLex and sLea levels linked to cat mammary tumors prognosis
By Yoshida, Saori et al.·Published in Journal of feline medicine and surgery·2014·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Aberrant expression of sLex and sLea as candidate prognostic factors for feline mammary gland tumour.
- Species:
- cat
Plain-English summary
A group of cats with mammary tumors showed higher levels of certain carbohydrate markers (sLe(x) and sLe(a)) compared to healthy cats. Researchers looked at tissue samples from 21 cats with mammary gland tumors and found that those with adenocarcinoma had significantly more of these markers. Additionally, blood tests indicated that cats with tumors had higher serum levels of sLe(x) than those with other health issues or healthy cats. While more research is needed, these markers could help predict the behavior of mammary tumors in cats.
People also search for: cat mammary tumor symptoms · feline adenocarcinoma treatment · high sLe(x) levels in cats
Abstract
Expression of the carbohydrate antigens sialyl Lewis x (sLe(x)) and a (sLe(a)) was evaluated in feline mammary gland tumours (FMGT). Immunohistochemical analysis of tissues from 21 FMGT patients and 11 healthy cats revealed significantly higher sLe(x) and sLe(a) antigen expression in adenocarcinoma tissues compared with that of normal mammary tissues (P <0.01). Serum concentration of sLe(x) was evaluated using an enzyme-linked immunosorbent assay and was significantly higher in the 11 FMGT patients (4.71 ± 10.1 U/ml) than the 22 patients with other disease (2.69 ± 1.59 U/ml) (P = 0.03) and the 22 healthy cats (3.71 ± 1.10 U/ml), although the latter difference was not significant. Although the number of cases examined in this study was small, our findings suggest that aberrant expression of sLe antigens may be induced by tumourigenesis in FMGT and that sLe antigens are potential prognostic tumour markers for FMGT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24043722/