Peer-reviewed veterinary case report
Dogs with acanthomatous ameloblastoma treated by bleomycin injections
By Kelly, J M et al.·Published in Veterinary and comparative oncology·2010·Veterinary Cancer Care, United States·View original on PubMed →
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Original publication title: Acanthomatous ameloblastoma in dogs treated with intralesional bleomycin.
- Species:
- dog
Plain-English summary
A group of dogs with a type of benign gum tumor called acanthomatous ameloblastoma (AA) received injections of a medication called bleomycin to see if it would help shrink the tumors. Out of seven dogs treated, six had complete tumor shrinkage within about 1.5 months, while one dog with a more advanced case saw a smaller reduction in tumor size after two weeks. The treatment was generally successful, with no local recurrences noted during the follow-up period of over two years. Some dogs experienced mild side effects like swelling and wound formation, but overall, bleomycin proved to be an effective option for treating this condition in dogs.
People also search for: dog gum tumor treatment · acanthomatous ameloblastoma in dogs · bleomycin for dog tumors
Abstract
Acanthomatous ameloblastoma (AA) is a benign gingival tumour that often invades bone. This retrospective study evaluated the efficacy of intralesional (IL) bleomycin as a treatment for AA. Six dogs received weekly or bimonthly IL bleomycin injections (dose range, 10-20 U m(-2)). A seventh dog presented with advanced, nonresectable AA was treated palliatively. One to sixteen treatments were administered (median, 5). Six of the seven dogs had a complete response within 4 months from initial IL injection (median, 1.5 months), whereas the palliative case had approximately 25% decrease in tumour volume 14 days from initial injection. Local recurrence was not observed during the study period, with a median follow-up time of 842 days. Adverse effects were limited to wound formation with bone exposure (n = 4), mild tissue reactions (n = 3), local swelling (n = 2) and local infection (n = 1). The conclusions of this study show IL bleomycin is an effective treatment for canines with AA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20579320/