Peer-reviewed veterinary case report
Dog develops bleeding problem from factor V inhibitors after stem
By Masciana, Joseph et al.·Published in Journal of veterinary internal medicine·2020·VCA West Los Angeles - Emergency and Critical Care, United States·View original on PubMed →
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Original publication title: Acquired factor V inhibitors after allogeneic hematopoietic stem cell transplantation in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old male Briard dog with B-cell lymphoma underwent a stem cell transplant but developed bleeding issues afterward. Despite receiving multiple blood transfusions, the dog continued to bleed due to acquired factor V inhibitors, which are proteins that interfere with blood clotting. The veterinarians managed the bleeding by using immunosuppressive treatment, and eventually, the dog's condition improved enough for him to go home. This case highlights the importance of monitoring for blood clotting issues in dogs receiving intensive treatments like stem cell transplants.
People also search for: dog lymphoma treatment · bleeding after dog stem cell transplant · factor V inhibitors in dogs
Abstract
OBJECTIVE: Describe the clinical course and management of a dog that underwent hematopoietic stem cell transplantation (HSCT) for treatment of B-cell lymphoma and developed acquired circulating factor V (FV) inhibitors. CASE SUMMARY: An 8-year-old male castrated Briard dog diagnosed with lymphoma (IVb, B-cell) presented for allogeneic HSCT. Despite multiple platelet, fresh frozen plasma, and red blood cell transfusions prolonged recovery and clinical bleeding occurred. Circulating acquired FV inhibitors were identified and hemorrhage subsequently was managed by immunosuppression. The dog was discharged when clinical resolution of bleeding was achieved. NEW OR UNIQUE INFORMATION PROVIDED: This case report describes a dog undergoing curative intent treatment for lymphoma, and subsequently acquiring factor inhibition, and was successfully managed. Specific coagulation screening to assess for coagulation factor deficiencies or inhibitors is essential in the diagnosis and treatment of patients with refractory bleeding or only transient response to blood transfusion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32686109/