Peer-reviewed veterinary case report
Acute Effect of Endotoxin on Selected Enzymes in the Guinea Pig
- Journal:
- American Journal of Veterinary Research
- Year:
- 1972
- Authors:
- Gupta, B. N. et al.
- Affiliation:
- From the Department of Large Animal Surgery and Medicine (Gupta and Conner), the Department of Pathology (Langham), and the Department of Anatomy (Echt), College of Veterinary Medicine, Michigan State University, East Lansing, Mich. 48823. · United States
- Species:
- rodent
Abstract
SUMMARY The acute effect of intramammary inoculation of endotoxin on activities of serum and mammary tissue enzymes of lactating guinea pigs was studied. Twenty-four hours after endotoxin was inoculated, glutamic oxalacetic transaminase (got), glutamic pyruvic transaminase (gpt), alkaline phosphatase (alp), acid phosphatase (acp), lactic dehydrogenase (ldh), isocitric dehydrogenase (icd), and creatine phosphokinase (cpk) activities in serum samples were determined. There was a significant increase in gpt activity due to endotoxin treatment. The serum activity for got was also increased. The serum activities for alp and acp were significantly decreased. There were apparently no differences in the activities of ldh and succinic dehydrogenase (sdh) in the mammary glands of endotoxin-treated and control guinea pigs. Increases in the serum concentrations of gpt and got in endotoxin-treated guinea pigs were indicative of cellular damage in various tissues.
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Search related cases →Original publication: https://doi.org/10.2460/ajvr.1972.33.08.1659