Peer-reviewed veterinary case report
Acute nonlymphocytic leukemia in a 1-year-old dog
By Hamlin, R H & Duncan, R C·Published in Journal of the American Veterinary Medical Association·1990·Spring Valley Veterinary Clinic·View original on PubMed →
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Original publication title: Acute nonlymphocytic leukemia in a dog.
- Species:
- dog
Plain-English summary
A 1-year-old Rhodesian Ridgeback was diagnosed with acute nonlymphocytic leukemia after showing symptoms like weight loss, lack of appetite, and extreme tiredness. Despite receiving chemotherapy treatments, including doxorubicin and cyclophosphamide, the dog's white blood cell count did not improve. Unfortunately, the dog required a blood transfusion, but despite these efforts, it passed away shortly after. The likely cause of death was related to complications from the leukemia.
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Abstract
Acute nonlymphocytic leukemia was diagnosed in a 1-year-old Rhodesian Ridgeback. Clinical signs of disease included weight loss, anorexia, lethargy, lymphadenopathy, splenomegaly, and hepatomegaly. Doxorubicin was administered IV on day 4 at a dosage of 30 mg/m2 of body surface, followed 2 days later by oral administration of cyclophosphamide at a dosage of 100 mg/m2. The cyclophosphamide was given for 4 consecutive days (days 8, 9, 10, and 11), but the WBC count did not respond. The dog was administered 500 ml of blood; but on day 12, it died. Necropsy was not performed, but the presumptive cause of death was related to leukostasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2295542/