Peer-reviewed veterinary case report
Acute monocytic ehrlichiosis in Beagles treated with rifampicin
By Karnezi, Dimitra et al.·Published in Veterinary microbiology·2016·Companion Animal Clinic·View original on PubMed →
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Original publication title: Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin.
- Species:
- dog
Plain-English summary
Ten Beagle dogs were studied after being infected with a tick-borne disease called canine monocytic ehrlichiosis (CME). Five of the dogs were treated with rifampicin, an antibiotic, for three weeks, while the other five received no treatment. Researchers looked at blood samples to see how certain proteins and antioxidants changed during treatment. They found that while some of these markers changed in the infected dogs, they didn't provide useful information about how well the treatment was working. Overall, the study suggests that these markers may not be reliable indicators of treatment response in dogs with CME.
People also search for: dog ehrlichiosis treatment · Beagle dog blood test results · rifampicin for dogs ehrlichiosis
Abstract
There is currently lack of information on the changes of acute phase proteins (APP) and antioxidant markers and their clinical relevance as treatment response indicators in canine monocytic ehrlichiosis (CME). The objective of this study was to investigate the patterns of C-reactive protein (CRP), haptoglobin (Hp), ferritin and paraoxonase-1 (PON-1) during treatment of dogs with acute CME with rifampicin. Blood serum samples from ten Beagle dogs with experimental acute CME were retrospectively examined. Five dogs (Group A) were treated with rifampicin (10mg/Kg/24h), per os, for 3 weeks and 5 dogs (Group B) received no treatment (infected controls). Two Beagle dogs served as uninfected controls. Blood serum samples were serially examined prior to Ehrlichia canis inoculation and on post-inoculation days 14, 21, 28, 35 and 42. Significant changes of CRP, Hp, ferritin and PON-1 values were found in the majority of infected dogs. However, their concentrations did not differ between the two groups during the treatment observation period. The results of this study indicate that although several APP and PON-1 tend to significantly change in the majority of dogs with acute CME, they were of limited clinical relevance as treatment response indicators in this experimental setting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26854345/