Peer-reviewed veterinary case report
Dog developed acute lung fluid after diazepam-ketamine anesthesia
By Boutureira, Joseph et al.·Published in Veterinary anaesthesia and analgesia·2007·Department of Small Animal Medicine, United States·View original on PubMed →
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Original publication title: Acute pulmonary edema after diazepam-ketamine in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old mixed-breed dog developed breathing problems after being put under anesthesia for a colonoscopy. Immediately after being intubated, frothy, reddish fluid came from the breathing tube, which stopped after a few minutes. The veterinarian treated the dog with a diuretic (furosemide) to help reduce fluid in the lungs, and further tests showed signs of pulmonary edema (fluid in the lungs). The next day, the dog had heart issues, including irregular heartbeats and high blood pressure in the lungs, likely caused by the anesthesia drugs. The dog required careful monitoring and treatment for these complications.
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Abstract
An 8-year-old mixed-breed dog was anesthetized for colonoscopy. Moderate sedation was produced by premedication with glycopyrrolate, acepromazine, and hydromorphone, and anesthesia was induced by IV injection of diazepam and ketamine. Frothy, reddish-colored fluid flowed from the endotracheal tube immediately after endotracheal intubation but ceased after several minutes. Furosemide was injected IV. Anesthesia was maintained by sevoflurane in oxygen. Ventilation and arterial blood pressure were satisfactory, however, after oxygen was administered to maintain normal hemoglobin saturation. Radiography revealed changes consistent with a diagnosis of pulmonary edema. The following day, ventricular premature contractions developed and atrial dissociation, valvular regurgitation, and pulmonary hypertension were diagnosed on echocardiography. The proposed etiology is either profound transient hypotension and/or pulmonary hypertension induced by ketamine. The cardiac abnormalities that were present the following day suggest that myocardial dysfunction after induction of anesthesia was more severe than was apparent as assessed by routine physical examination and monitoring methods.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17565575/