Peer-reviewed veterinary case report
Seizures in two dogs right after S-ketamine anesthesia induction
By Adami, C et al.·Published in Schweizer Archiv fur Tierheilkunde·2013·Department of Veterinary Clinical Science·View original on PubMed →
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Original publication title: Seizure activity occurring in two dogs after S-ketamine-induction.
- Species:
- dog
Plain-English summary
Two healthy dogs experienced seizures right after being put under anesthesia for surgery. The first dog showed severe muscle spasms, drooling, urination, defecation, and a rise in body temperature. The second dog had twitching in its face and increased muscle stiffness, along with drooling and urination. Thankfully, both dogs recovered from anesthesia without any further seizures. This situation suggests that the anesthetic drug S-ketamine may have triggered the seizures, even though other causes were ruled out.
People also search for: dog seizure after anesthesia · S-ketamine side effects in dogs · dog anesthesia recovery issues
Abstract
Two healthy dogs were anaesthetized to undergo elective orthopaedic procedures. After premedication with methadone and acepromazine, general anaesthesia was induced with midazolam and S-ketamine. Immediately after anaesthetic induction, seizures occurred in both dogs. In the first dog the syndrome was characterized by tonic and clonic motor activity, muscular hypertone, hypersalivation, urination, defecation and hyperthermia. In the second dog muscular twitches of the temporal and masseter regions were observed, followed by increased skeletal muscles tone, hypersalivation, spontaneous urination and increase in body temperature. Recoveries from anaesthesia were uneventful and no seizures were observed. Considering the temporal association between anaesthetic induction and occurrence of seizures, and the fact that other causative factors could not be identified, it is hypothesized that S-ketamine played a role in determining the convulsive phenomena observed in these patients. S-ketamine might carry the potential for inducing seizures in otherwise healthy dogs, despite the concomitant use of GABA-ergic drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24091232/