Peer-reviewed veterinary case report
Acute tumor lysis syndrome in a dog with B-cell lymphoma
By Mylonakis, M E et al.·Published in Australian veterinary journal·2007·Companion Animal Clinic·View original on PubMed →
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Original publication title: Acute tumour lysis syndrome in a dog with B-Cell multicentric lymphoma.
- Species:
- dog
Plain-English summary
A 5-year-old spayed female German Shepherd was taken to the vet because she had swollen lymph nodes and an enlarged spleen. She was diagnosed with advanced B-cell lymphoma and initially treated with a combination of chemotherapy drugs, but it didn't work well. After switching to a different chemotherapy plan, her condition suddenly worsened, leading to severe symptoms like bleeding, jaundice, and kidney issues, although her swollen lymph nodes shrank completely. This situation highlights a rare but serious condition called acute tumor lysis syndrome that can occur in dogs undergoing cancer treatment.
People also search for: dog lymphoma treatment · German Shepherd swollen lymph nodes · acute tumor lysis syndrome in dogs
Abstract
A 5-year-old, spayed female German Shepherd dog was admitted to hospital with marked generalised lymphadenomegaly and splenomegaly. A stage Va B-cell multicentric lymphoma was diagnosed on clinical, cytological (lymph node, bone marrow), histological-immunohistochemical (lymph node excision) and imaging grounds. Since no satisfactory remission was achieved using a multi-drug chemotherapy protocol that included cyclophosphamide, vincristine, cytosine arabinoside, prednisolone, and subsequently supplemented by L-asparaginase, it was replaced by another protocol combining vincristine, L-asparaginase, prednisolone, cyclophosphamide and doxorubicin. Soon after the third weekly session of the second protocol, the clinical status of the animal deteriorated suddenly and severely, with a bleeding tendency, jaundice, hyperuricaemia, hyperphosphataemia, azotaemia, hyperbilirubinaemia and, presumptive disseminated intravascular coagulation. There was also complete regression of lymphadenomegaly. This report emphasises the clinicopathological features and the diagnostic peculiarities of the acute tumour lysis syndrome, which occurs uncommonly in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17470071/