Peer-reviewed veterinary case report
Adding pamidronate to carboplatin chemo after dog limb amputation
By Kozicki, A. R. et al.·Published in Veterinary and Comparative Oncology·2013·Department of Medical Sciences University of Wisconsin‐Madison Madison WI USA, United States·View original on Crossref →
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Original publication title: Adjuvant therapy with carboplatin and pamidronate for canine appendicular osteosarcoma
- Species:
- dog
Plain-English summary
A group of 17 dogs with appendicular osteosarcoma (a type of bone cancer) underwent limb amputation followed by chemotherapy with carboplatin, and some received an additional treatment called pamidronate. The study found that adding pamidronate did not cause any side effects and did not reduce the effectiveness of the carboplatin treatment. The dogs treated with both medications had a median survival time of about 311 days, which was similar to the 294 days for those receiving carboplatin alone. This suggests that pamidronate can be safely added to the treatment plan for dogs with this type of cancer.
People also search for: dog bone cancer treatment · osteosarcoma in dogs · carboplatin and pamidronate for dogs
Abstract
AbstractAmputation and chemotherapy are the mainstay of treatment for canine appendicular osteosarcoma (OSA).In vitrostudies have demonstrated anti‐tumour activity of pamidronate against canineOSA. The purpose of this study was to assess the safety of adding pamidronate to standard post‐operative carboplatin chemotherapy in 17 dogs with appendicularOSAtreated with limb amputation. Median disease‐free interval (DFI) and median survival time (MST) were evaluated as secondary endpoints. Incidence of side effects and treatment outcomes were compared to 14 contemporary control patients treated with carboplatin alone. There were no identified side effects to the pamidronate treatment. The medianDFIfor the study group was 185 days compared to 172 days for the control group (P= 0.90). TheMSTof the study group was 311 days compared to 294 days for the control group (P= 0.89). Addition of pamidronate to carboplatin chemotherapy for the treatment of canine appendicularOSAis safe and does not impair efficacy of standard carboplatin treatment.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.12040