Peer-reviewed veterinary case report
Fenoldopam treatment in dogs and cats with acute kidney injury
By Nielsen, Lindsey K et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2015·Angell Animal Medical Center·View original on PubMed →
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Original publication title: Administration of fenoldopam in critically ill small animal patients with acute kidney injury: 28 dogs and 34 cats (2008-2012).
Plain-English summary
A group of 28 dogs and 34 cats with acute kidney injury (AKI) were treated with a medication called fenoldopam to see if it would help them recover. After treatment, about 39% of the dogs and 38% of the cats survived and were able to go home. While fenoldopam was generally safe, it didn't show any significant benefits in improving survival rates or kidney function compared to pets that didn't receive this treatment. Some pets experienced low blood pressure as a side effect, but overall, the medication didn't lead to better outcomes for these critically ill animals.
People also search for: dog acute kidney injury treatment · cat kidney failure medication · fenoldopam for dogs and cats
Abstract
OBJECTIVE: To describe the clinical features and outcomes of critically ill dogs and cats with acute kidney injury (AKI) receiving fenoldopam infusions compared to patients with AKI that did not receive fenoldopam. DESIGN: Retrospective clinical study from May 1, 2008 until June 1, 2012. SETTING: Private emergency and specialty referral hospital. ANIMALS: Client-owned dogs (28) and cats (34) with AKI that received fenoldopam compared with similar patients with AKI (30 dogs and 30 cats) that did not. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The medical records of 62 critically ill dogs and cats with AKI that received fenoldopam were reviewed. Presenting clinical signs, physical examination findings, and primary and secondary disease processes were identified in all patients. The mean number of days on fenoldopam was 1.5 days (range 0.3-4.0 days) for dogs and 1.9 days (range 1.0-4.0 days) for cats. Eleven of 28 (39%) dogs survived to discharge and 13 of 34 (38%) of the cats survived to discharge. Of the animals in the group receiving fenoldopam that died, the majority (84%) were euthanized. Potential adverse reactions were evaluated, with hypotension being the most commonly encountered adverse effect (7% of fenoldopam group [FG] dogs and 23% of FG cats). When compared with patients with AKI that did not receive fenoldopam, no significant differences were found between the groups with regards to survival, length of hospital stay, adverse effects, or changes in creatinine, BUN, or sodium concentrations except that patients receiving fenoldopam were significantly more likely to have received other renally active medications. CONCLUSIONS: In this study of patients with AKI, fenoldopam administration at 0.8 μg/kg/min in dogs and 0.5 μg/kg/min in cats appeared relatively safe but was not associated with improvement in survival to discharge, length of hospital stay, or improvement in renal biochemical parameters when compared to patients with AKI not receiving fenoldopam.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25854861/