Peer-reviewed veterinary case report
Nitrofurantoin treatment for dogs with resistant urinary infections
By Leuin, A S et al.·Published in The Journal of small animal practice·2021·Veterinary Specialty Hospital - North County, United States·View original on PubMed →
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Original publication title: Administration of nitrofurantoin in dogs with lower urinary tract infections: 14 cases (2013-2019).
- Species:
- dog
Plain-English summary
A group of 14 dogs with recurrent urinary tract infections were treated with nitrofurantoin, an antibiotic effective against certain bacteria. Most of the dogs showed improvement, with 12 out of 14 experiencing successful outcomes, including complete resolution of the infection in nine dogs. The treatment involved giving nitrofurantoin every eight hours for 14 days. However, two dogs did not respond well due to the bacteria becoming resistant to the medication. This highlights the importance of testing the bacteria to ensure the right antibiotic is used.
People also search for: dog urinary tract infection treatment · nitrofurantoin for dogs · recurrent UTI in dogs
Abstract
OBJECTIVES: The purpose of this study was to describe the clinical use of nitrofurantoin in client-owned dogs with lower urinary tract infections. The primary aim was to describe the patient population, dosage, treatment duration, outcome and side effects. MATERIALS AND METHODS: Medical records in an institution were retrospectively reviewed from July 2013 to January 2019. RESULTS: Nitrofurantoin was prescribed in this clinical population of 14 client-owned dogs for lower urinary tract infections. Recurrent urinary tract infection was the clinical diagnosis in all dogs. Each dog's urinary tract infection was associated with a nitrofurantoin-susceptible, multidrug-resistant uropathogen. The median dosage and duration of nitrofurantoin treatment was 4.3 mg/kg by mouth every 8 hours for 14 days. Twelve of the 14 dogs had successful outcomes including bacteriologic cure (n = 9), clinical cure (2) and resolution of target bacteria (1). Treatment failures (n = 2) were associated with uropathogens developing progressive nitrofurantoin resistance. CLINICAL SIGNIFICANCE: In some dogs with recurrent lower urinary tract infections, nitrofurantoin may be an effective antibiotic for treatment of nitrofurantoin-susceptible uropathogens. Treatment failures were associated with progressive uropathogen resistance. Urine bacterial culture and quantitative susceptibility testing are essential to initiating and monitoring treatment due to the multidrug-resistant isolates and, in some cases, persistent bacteriuria in the face of treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33107048/