Peer-reviewed veterinary case report
Urinary side effects of allopurinol in dogs with leishmaniasis
By Torres, M et al.·Published in The Journal of small animal practice·2016·Hospital Veterinari Balmes, Spain·View original on PubMed →
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Original publication title: Adverse urinary effects of allopurinol in dogs with leishmaniasis.
- Species:
- dog
Plain-English summary
A group of dogs being treated for leishmaniasis (a parasitic disease) with allopurinol developed urinary problems, including xanthinuria (high levels of a substance called xanthine in urine), kidney stones, and mineral buildup in the kidneys. Out of 320 dogs treated, 42 experienced these adverse effects, with nearly half showing signs like difficulty urinating. It's important for pet owners to monitor their dogs for any urinary issues while on allopurinol, as these complications can arise during treatment. Regular check-ups with the veterinarian can help catch these problems early.
People also search for: dog leishmaniasis treatment · allopurinol side effects in dogs · dog urinary problems after medication
Abstract
OBJECTIVE: The objective of this study was to describe the adverse effects of allopurinol on the urinary system during treatment of canine leishmaniasis. METHODS: Retrospective case series of 42 dogs that developed xanthinuria while receiving allopurinol treatment for leishmaniasis. RESULTS: Of 320 dogs diagnosed with leishmaniasis, 42 (13%) developed adverse urinary effects. Thirteen (of 42) dogs (31%) developed xanthinuria, renal mineralisation and urolithiasis; 11 (26·2%) showed xanthinuria with renal mineralisation; 9 (21·4%) had xanthinuria with urolithiasis and 9 (21·4%) developed xanthinuria alone. Urinary clinical signs developed in 19 dogs (45·2%). CLINICAL SIGNIFICANCE: This study demonstrates that urolithiasis and renal mineralisation can occur in dogs receiving allopurinol therapy. Dogs receiving therapy should be monitored for the development of urinary adverse effects from the beginning of treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27112522/