Peer-reviewed veterinary case report
Aggressive skin tumor in young male Labrador retriever
By Otrocka-Domagala, I et al.·Published in Journal of comparative pathology·2015·Department of Pathological Anatomy·View original on PubMed →
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Original publication title: Aggressive, solid variant of alveolar rhabdomyosarcoma with cutaneous involvement in a juvenile labrador retriever.
- Species:
- dog
Plain-English summary
An 8.5-month-old male Labrador retriever was brought to the vet with a mass on his face and swollen gums. Despite receiving antibiotics and anti-inflammatory medication, the dog developed more skin tumors on his neck, trunk, and groin after three weeks. A biopsy revealed that these tumors were a type of aggressive cancer called alveolar rhabdomyosarcoma. Unfortunately, due to the widespread nature of the disease, the dog was humanely euthanized. This case highlights a rare form of cancer in dogs that can affect the skin and other organs.
People also search for: Labrador retriever skin tumor · dog cancer treatment options · why is my dog developing lumps
Abstract
An 8.5-month-old male Labrador retriever presented with a cutaneous mass in the right maxillofacial region and swelling of the gingiva. The dog received antibiotic and anti-inflammatory treatment. After 3 weeks the dog returned, presenting with disseminated cutaneous tumours on the neck, trunk and groin. One of the nodules was resected and a cutaneous round cell tumour was diagnosed on microscopical examination. The dog was humanely destroyed. Necropsy examination revealed disseminated tumours in the skin, internal organs and skeletal muscles. Microscopically, all of the tumours were composed of small round cells, arranged in nests. Immunohistochemically, the neoplastic cells expressed vimentin, desmin, MyoD1, myogenin and smooth muscle actin, but were negative for CD3, CD18, CD79αcy, cytokeratin AE1/AE3, chromogranin A, class II molecules of the major histocompatibility complex, neuron-specific enolase and S100. The average Ki67 index was 89.5%. The final diagnosis was a solid variant of alveolar rhabdomyosarcoma (ARMS). This is the first report of the cutaneous multifocal form of ARMS in veterinary oncology.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25555631/