Peer-reviewed veterinary case report
Endocannabinoid changes in spinal fluid of dogs with epilepsy
By Gesell, Felix K et al.·Published in BMC veterinary research·2013·Department of Small Animal Medicine and Surgery, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder.
- Species:
- dog
Plain-English summary
A group of dogs with epilepsy were studied to see if their cerebrospinal fluid had different levels of certain natural compounds called endocannabinoids, which help control seizures. The researchers found that dogs with epilepsy had higher levels of one specific endocannabinoid compared to healthy dogs, and these levels were linked to how severe and long-lasting their seizures were. This suggests that the endocannabinoid system may not work properly in dogs with epilepsy. Understanding these changes could help veterinarians find better treatments for managing seizures in affected dogs.
People also search for: dog epilepsy treatment · why is my dog having seizures · endocannabinoids in dogs · managing dog seizures · dog seizure severity
Abstract
BACKGROUND: Epilepsy is one of the most common chronic neurological disorders in dogs characterized by recurrent seizures. The endocannabinoid (EC) system plays a central role in suppressing pathologic neuronal excitability and in controlling the spread of activity in an epileptic network. Endocannabinoids are released on demand and their dysregulation has been described in several pathological conditions. Recurrent seizures may lead to an adverse reorganization of the EC system and impairment of its protective effect. In the current study, we tested the hypothesis that cerebrospinal fluid (CSF) concentrations of the endocannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2AG) are altered in epileptic dogs. Concentrations of AEA and total AG (sum of 2AG and 1AG) were measured in 40 dogs with idiopathic epilepsy and in 16 unaffected, healthy control dogs using liquid chromatography combined with tandem mass spectrometry. RESULTS: AEA and total AG were measured at 4.94 (3.18 - 9.17) pM and 1.43 (0.90 - 1.92) nM in epileptic dogs and at 3.19 (2.04 - 4.28) pM and 1.76 (1.08 - 2.69) nM in the control group, respectively (median, 25 - 75% percentiles in brackets). The AEA difference between epileptic and healthy dogs was statistically significant (p < 0.05). Values correlated with seizure severity and duration of seizure activity. Dogs with cluster seizures and/or status epilepticus and with seizure activity for more than six months displayed the highest EC concentrations. CONCLUSION: In conclusion, we present the first endocannabinoid measurements in canine CSF and confirm the hypothesis that the EC system is altered in canine idiopathic epilepsy.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24370333/