Peer-reviewed veterinary case report
Serum and urine changes in dogs with chronic gut disease
By Gori, Eleonora et al.·Published in Open veterinary journal·2022·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: Alterations of selected serum biochemical and urinary parameters in dogs with chronic enteropathy.
- Species:
- dog
Plain-English summary
A group of dogs with chronic enteropathy (CE), a condition affecting their intestines, were examined for changes in their blood and urine tests. Among the 90 dogs studied, many had reduced muscle condition and some showed signs of protein in their urine, which can indicate kidney issues. However, there wasn't a clear link between their gastrointestinal symptoms and urinary problems. Dogs with a specific type of CE that causes protein loss in the intestines were found to have a higher chance of showing protein in their urine compared to those without this condition. More research is needed to understand the connection between gut and kidney health in these dogs.
People also search for: dog chronic enteropathy symptoms · dog protein in urine treatment · signs of kidney problems in dogs
Abstract
BACKGROUND: No specific study on concurrent nephropathy has been conducted in dogs with chronic enteropathy (CE), except for soft-coated Wheaten Terriers. Moreover, limited information exists regarding the urinary profile in dogs with CE. AIM: To describe, compare, and discuss the alterations in selected serum biochemical and urinary parameters in dogs with CE. METHODS: Multicentric retrospective study on dogs with CE diagnosed after exclusion of extra-gastrointestinal diseases. In addition, dogs with azotemia and lower urinary tract diseases were excluded. Information on canine chronic enteropathy clinical activity index (CCECAI) score, muscular condition score (MCS), presence of glycosuria, proteinuria [urine protein-to-creatinine (UPC) ratio > 0.5], and/or cylindruria (>1-2 casts/hpf) at diagnosis were gleaned from the medical records. Dogs were retrospectively classified as food-responsive enteropathy, immunosuppressant-responsive enteropathy, or nonresponsive enteropathy based on the presence of gastrointestinal histological inflammation and the treatment response. In addition, based on the serum albumin concentration (ALB), dogs were classified as having protein-losing enteropathy (PLE). RESULTS: Ninety CE dogs were included. Fifty-two dogs had mild-to-severely decreased MCS and 38 dogs showed altered urinary parameters. No significant associations were found between CCECAI and altered urinary parameters. No significant association was found between PLE dogs and altered urinary parameters. PLE dogs showed higher prevalence of proteinuria than non-PLE dogs (= 0.03; OR = 2.8; 95% CI = 1-6.8). CONCLUSION: Despite the presence of altered urinary profile in dogs with CE, further studies are needed to explore a possible link between gastrointestinal and renal inflammation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36118717/