Peer-reviewed veterinary case report
Chemotherapy with carboplatin and doxorubicin after limb surgery
By Kent, Michael S et al.·Published in Journal of veterinary internal medicine·2004·Department of Surgical and Radiological Sciences, United States·View original on PubMed →
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Original publication title: Alternating carboplatin and doxorubicin as adjunctive chemotherapy to amputation or limb-sparing surgery in the treatment of appendicular osteosarcoma in dogs.
- Species:
- dog
Plain-English summary
A group of 32 dogs with bone cancer in their legs (appendicular osteosarcoma) underwent either amputation or limb-sparing surgery, followed by chemotherapy using alternating doses of carboplatin and doxorubicin every three weeks for a total of three cycles. The dogs had a median survival time of about 320 days, with some living up to 487 days after treatment. The chemotherapy caused minimal side effects, making it a potentially effective option for dogs with this type of cancer.
People also search for: dog bone cancer treatment · appendicular osteosarcoma chemotherapy · dog amputation recovery time
Abstract
Thirty-two dogs with appendicular osteosarcoma treated by amputation or limb sparing had adjuvant chemotherapy of alternating doses of carboplatin (300 mg/m2 IV) and doxorubicin (30 mg/m2 IV) every 21 days for a total of 3 cycles. Efficacy, toxicity, and previously identified prognostic factors for osteosarcoma were evaluated. The median progression free survival was 227 days (range 180-274), and the median overall survival was 320 days (range 153-487). The 1-year survival rate was 48%, and the 2-year survival rate was 18%. Age, sex, surgical procedure, and alkaline phosphatase activity above the reference ranges were not prognostic for survival. There was minimal toxicity associated with the chemotherapy. This protocol could be useful for the adjuvant treatment of appendicular osteosarcoma of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15320595/