Peer-reviewed veterinary case report
Shar-Pei dog with kidney failure from amyloidosis and infections
By J.L. Reis Jr. et al.·Published in Arquivo Brasileiro de Medicina Veterinária e Zootecnia·2001·View original on DOAJ →
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Original publication title: Amiloidose renal em cão Shar-Pei: Relato de Caso Renal amyloidosis in a Shar-Pei dog: A case report
- Species:
- dog
Plain-English summary
A 9-year-old male Shar-Pei was brought in showing signs of kidney failure, including lethargy, dehydration, and not urinating. He also had a history of skin infection and tested positive for leishmaniasis and ehrlichiosis. Sadly, the dog passed away, and a necropsy revealed kidney damage with signs of amyloidosis, which is a buildup of abnormal proteins. This condition can be hereditary in Shar-Peis or linked to chronic inflammation from infections. Unfortunately, there was no successful treatment in this case, as the dog’s condition was severe by the time of diagnosis.
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Abstract
O presente relato descreve os achados clínicos e anatomopatológicos de um caso de amiloidose renal em um cão macho de nove anos da raça Shar-Pei. O animal apresentava quadro clínico de esporotricose e de insuficiência renal e exames positivos para erlichiose e leishmaniose. No dia anterior ao óbito, o cão apresentou apatia, desidratação e anúria. À necropsia foram observados inúmeros pontos milimétricos esbranquiçados localizados no córtex renal e hepatização do lobo diafragmático esquerdo. O achado histológico mais importante foi deposição de material eosinofílico, amorfo e acelular localizado nos tufos glomerulares que se corou positivamente pelo vermelho congo (amilóide). Observaram-se nefrite supurada multifocal, espessamento da cápsula de Bowman e broncopneumonia supurada crônica, com fibrose intensa. A origem da amiloidose, no presente caso, poderia ser hereditária, assemelhando-se à amiloidose familiar descrita em cães da raça Shar-Pei, ou ser devida à inflamação supurada crônica e/ou leishmaniose.<br>The clinical and pathological findings of a case of renal amyloidosis in a nine-year-old male Shar-Pei dog were described. Clinically, there were signs of sporotrichosis and renal insufficiency, besides being positive to leishmaniasis and ehrlichiosis. On the day before death, the animal became apathetic, dehydrated and anuric. On gross examination, there were several whitish millimetric spots seen widespread in both renal cortices and consolidation of the left diaphragmatic pulmonary lobe. The most important microscopic finding was a deposition of amorphous acellular material on the glomerular tufts which stained positively by congo red stain. Other changes were multifocal suppurative nephritis, thickening of the Bowman capsule and chronic suppurative bronchopneumonia. The origin of the amyloidosis in this case could be hereditary, being similar to familiar amyloidosis described in Shar-Pei breed, or due to chronic suppurative inflammation and/or leishmaniasis.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1590/S0102-09352001000400005