Peer-reviewed veterinary case report
Amino acid levels in dogs with protein-losing kidney disease
By Parker, Valerie J et al.·Published in Journal of veterinary internal medicine·2019·The Ohio State University, United States·View original on PubMed →
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Original publication title: Amino acid status in dogs with protein-losing nephropathy.
- Species:
- dog
Plain-English summary
A group of dogs with kidney disease known as protein-losing nephropathy (PLN) were found to have lower levels of important amino acids compared to healthy dogs. This condition can lead to malnutrition, as these amino acids are essential for the dog's health. The study suggests that adding amino acid supplements to the treatment plan for dogs with PLN might help improve their overall health and manage their condition better. If your dog has kidney issues, discussing amino acid supplementation with your veterinarian could be beneficial.
People also search for: dog kidney disease treatment · protein-losing nephropathy in dogs · amino acid supplements for dogs with kidney disease
Abstract
BACKGROUND: Proteinuria in dogs with kidney disease can contribute to protein-energy wasting and malnutrition. Little is known about amino acid (AA) status in dogs with protein-losing nephropathy (PLN). OBJECTIVES: The purpose of our study was to further elucidate AA status in PLN dogs, with the hypothesis that PLN dogs would have altered AA status as compared to healthy dogs. ANIMALS: Thirty client-owned PLN dogs were compared to 10 healthy control dogs. METHODS: Prospective observational study. Dogs with PLN that were presented to the teaching hospital were enrolled. Plasma AA profiles were measured using an automated high-performance liquid chromatography AA analyzer. RESULTS: Compared to control dogs, PLN dogs had significantly lower concentrations of leucine, threonine, histidine, glycine, proline, asparagine, tyrosine, o-hydroxyproline, and serine, as well as sums of both essential and nonessential AA (P < .05). Dogs with PLN had significantly lower ratios of tyrosine-to-phenylalanine and glycine-to-serine (P < .05), and a significantly greater ratio of valine-to-glycine (P < .05). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with PLN have altered AA status compared to healthy dogs. These findings could have therapeutic implications in determining optimal management of PLN dogs, such as providing AA supplementation along with other standard treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30784117/