Peer-reviewed veterinary case report
Dog with fever and lethargy after incompatible blood transfusion due
By Giger, U et al.·Published in Journal of the American Veterinary Medical Association·1995·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: An acute hemolytic transfusion reaction caused by dog erythrocyte antigen 1.1 incompatibility in a previously sensitized dog.
- Species:
- dog
Plain-English summary
A dog that had received a blood transfusion three years earlier developed a serious reaction after getting another transfusion. The dog showed symptoms like fever, dark urine, and lethargy, and its red blood cell count didn’t improve as expected. Tests revealed that the blood from the donor was incompatible due to a specific blood type issue. To prevent such reactions in the future, it's important for vets to crossmatch blood types before transfusions, especially in dogs that have had previous transfusions.
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Abstract
An acute hemolytic transfusion reaction resulting from dog erythrocyte antigen (DEA) 1.1 incompatibility developed in a dog previously sensitized to DEA 1.1 by a transfusion 3 years earlier. The dog developed fever, pigmenturia, and lethargy, and its PCV did not rise as expected. The donor blood was type DEA 1.1 positive, whereas the recipient's blood was type DEA 1.1, DEA 1.2, and DEA 7 negative. A major crossmatch was later found to be strongly incompatible. Studies of the recipient's plasma revealed a specific anti-DEA 1.1 alloantibody of the IgG class with high hemolysin and agglutinin activity. Such acute hemolytic transfusion reactions can be avoided by crossmatching previously transfused dogs and by using dogs that are type DEA 1.1 negative (and preferably also type DEA 1.2 and DEA 7 negative) as blood donors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7775248/