Peer-reviewed veterinary case report
An artificial nickel chlorinase based on the biotin-streptavidin technology.
- Year:
- 2024
- Authors:
- Yu K et al.
- Affiliation:
- Department of Chemistry
Abstract
Herein, we report on an artificial nickel chlorinase (ANCase) resulting from anchoring a biotinylated nickel-based cofactor within streptavidin (Sav). The resulting ANCase was efficient for the chlorination of diverse C(sp<sup>3</sup>)-H bonds. Guided by the X-ray analysis of the ANCase, the activity of the artificial chlorinase could be significantly improved. This approach opens interesting perspectives for late-stage functionalization of organic intermediates as it complements biocatalytic chlorination strategies.
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Search related cases →Original publication: https://europepmc.org/article/MED/38277163