Peer-reviewed veterinary case report
New canine papillomavirus with cancer risk found in golden retriever
By Yuan, Hang et al.·Published in Virology·2007·Department of Pathology, United States·View original on PubMed →
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Original publication title: An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus.
- Species:
- dog
Plain-English summary
A golden retriever developed growths on its footpads, which were found to be caused by a newly identified virus called CfPV-2. This virus is different from the more common canine oral papillomavirus and can lead to serious issues, including the potential for the growths to turn into cancer if the infection persists. The discovery of this virus allows veterinarians to better understand how it affects dogs and how to treat it. Currently, there is no specific treatment mentioned for the virus, but monitoring and managing the growths is essential for the dog's health.
People also search for: dog footpad growths · golden retriever papilloma treatment · canine papillomavirus symptoms
Abstract
A novel canine papillomavirus, CfPV-2, was cloned from a footpad lesion of a golden retriever. Unlike the known canine oral papillomavirus (COPV), which has a double-stranded DNA genome size of 8607 bps, the genome of CfPV-2 is 8101 bps. Some of this size difference is due to an abbreviated early-late region (ELR), which is 1200 bps shorter than that of COPV. However, CfPV-2 has other differences from COPV, including the presence of an E5 ORF between the E2 gene and the ELR and an enlarged E4 ORF (one of the largest PV E4 open reading frames). The genome of CfPV-2 shares low homology with all the other papillomaviruses and, even in the most highly conserved ORF of L1, the nucleotide sequence shares only 57% homology with COPV. Due to this highly divergent DNA sequence, CfPV-2 establishes a new PV genus, with its closest phylogenetic relatives being amongst the Xi and Gamma genuses. CfPV-2 also has unique biological features; it induces papillomas on footpads and interdigital regions which, if infection is persistent, can progress to highly metastatic squamous cell carcinoma. CfPV-2 does not induce oral papillomas in immunocompetent animals and antibodies generated against COPV and CfPV-2 are type-specific. The availability of a new canine papillomavirus with differing genetic and biological properties now makes it possible to study type-specific host immune responses, tissue tropism and the comparative analysis of viral gene functions in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17034826/