Peer-reviewed veterinary case report
An oral Sindbis virus replicon-based DNA vaccine containing VP2 gene of canine parvovirus delivered by Escherichia coli elicits immune responses in dogs.
- Journal:
- Acta virologica
- Year:
- 2011
- Authors:
- Dahiya, S S et al.
- Affiliation:
- Indian Veterinary Research Institute · India
- Species:
- dog
Abstract
A Sindbis virus replicon-based DNA vaccine containing VP2 gene of canine parvovirus (CPV) was delivered by Escherichia coli to elicit immune responses. The orally immunized dogs developed CPV-specific serum IgG and virus neutralizing antibody responses. The cellular immune responses analyzed using lymphocyte proliferation test and flow cytometry indicated CPV-specific sensitization of both CD3+CD4+ and CD3+CD8+ lymphocytes. This study demonstrated that the oral CPV DNA vaccine delivered by E. coli can be considered as a promising approach for vaccination of dogs against CPV.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22149493/