Peer-reviewed veterinary case report
Golden Retriever dog with brain mass causing seizures
By Scott, Steven J et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2015·Canada (Godson)Western College of Veterinary Medicine, Australia·View original on PubMed →
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Original publication title: An unusual lipomatous brain mass in a Golden Retriever dog.
- Species:
- dog
Plain-English summary
A 9-year-old Golden Retriever was brought in after experiencing grand mal seizures for three weeks. Unfortunately, the dog was euthanized, and during the autopsy, a firm mass was discovered in the brain that was pressing on important areas. The mass was made up of fat tissue and was identified as a lipomatous hamartoma, which is a type of abnormal growth. Sadly, due to the severity of the condition, the dog did not recover.
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Abstract
A 9-year-old Golden Retriever dog was presented to the Veterinary Medical Center with a 3-week history of grand mal seizures and was subsequently euthanized. At autopsy, a discrete, firm, expansile mass was found in the right pyriform lobe, which compressed the ipsilateral hippocampus, thalamus, and cerebral cortex. Histologically, the mass was composed of well-differentiated adipose tissue supported by fibrous and mucinous stroma. Adipocytes exhibited strong immunoreactivity for vimentin and were negative for pancytokeratin (AE1/AE3), glial fibrillary acidic protein, neuron-specific enolase, and synaptophysin. These findings are most compatible with an intracranial lipomatous hamartoma, which is an extraparenchymal lesion that has been identified in several species. The current report describes an intracerebral lipomatous hamartoma in a veterinary species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26450836/