Peer-reviewed veterinary case report
Analysis of the codon usage of the ORF2 gene of feline calicivirus.
- Journal:
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Year:
- 2017
- Authors:
- Zang, Minghui et al.
- Affiliation:
- College of Veterinary Medicine · China
- Species:
- cat
Abstract
Feline calicivirus (FCV) is a highly prevalent pathogen of the domestic cat that causes acute infections of the oral and upper respiratory tract. The E region of the ORF2 protein is responsible for the induction of virus-neutralizing antibodies, thus it is important to understand the codon usage of this gene. Here, analysed 90 coding sequences of ORF2 and show that it undergoes a low codon usage bias. In addition, although mutational bias is one of the factors shaping the codon usage bias of this gene, natural selection plays a more significant role. Our results reveal part of the mechanisms driving FCV evolution, which will lay foundation for the further research of FCV.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28625542/