Peer-reviewed veterinary case report
Angiocentric astrocytoma brain tumor in a cat with seizures
By Rissi, Daniel R et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2019·Department of Pathology (Rissi, United States·View original on PubMed →
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Original publication title: Angiocentric astrocytoma in a cat.
- Species:
- cat
Plain-English summary
A 15-year-old spayed female domestic shorthaired cat was brought in for severe seizures that did not respond to treatment. Unfortunately, the cat was diagnosed with a rare type of brain tumor called an angiocentric astrocytoma, which caused swelling in the brain. Despite attempts to manage her condition, the seizures persisted, leading to the difficult decision to euthanize her. This case highlights the challenges of treating certain brain tumors in cats, especially when they are resistant to therapy.
People also search for: cat seizures treatment · brain tumor in cats · angiocentric astrocytoma symptoms
Abstract
Gliomas are common primary central nervous system neoplasms of dogs and cats, but atypical glioma subtypes are rare. Herein we report an angiocentric astrocytoma in a 15-y-old spayed female domestic shorthaired cat that was euthanized after therapy-resistant seizures. Gross anatomic changes consisted of swelling of the rostral leptomeninges over the olfactory bulbs and rostral telencephalon. Histologically, polygonal-to-elongate atypical neoplastic cells were arranged along perivascular spaces within these areas. Neoplastic cells were positive for glial fibrillary acidic protein, S100 protein, and vimentin. Ultrastructurally, round-to-elongate neoplastic cells emitting long processes with aggregates of intermediary filaments expanded and occupied the spaces between the vascular basement membrane and the glia limitans; nuclei had marginal and central heterochromatin. Tight junctions connected the plasma membrane of neighboring cells. The cell morphology, immunohistochemistry, and ultrastructural findings were consistent with an astrocytoma; the exclusive perivascular arrangement of neoplastic cells with no parenchymal mass warranted the diagnosis of angiocentric astrocytoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31018782/