Peer-reviewed veterinary case report
ACE inhibitors for treating kidney disease in dogs and cats
By Lefebvre, H P & Toutain, P L·Published in Journal of veterinary pharmacology and therapeutics·2004·UMR 181 Physiopathologie et Toxicologie Experimentales INRA-ENVT, France·View original on PubMed →
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Original publication title: Angiotensin-converting enzyme inhibitors in the therapy of renal diseases.
Plain-English summary
A dog with chronic kidney disease (CRF) may experience symptoms like increased thirst, frequent urination, and weight loss. Angiotensin-converting enzyme inhibitors (ACEIs) are often prescribed to help manage this condition by reducing high blood pressure in the kidneys and slowing down kidney damage. Research shows that ACEIs can be effective in improving kidney function and overall health in dogs with CRF. However, it's important for veterinarians to monitor these dogs closely for any potential side effects, especially if they are on a low sodium diet or other medications.
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Abstract
Renal diseases, especially chronic renal failure (CRF), are common in canine and feline medicine. The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in these conditions in the development of renal lesions and the progression of kidney dysfunction. Angiotensin-converting enzyme inhibitors (ACEI) are currently considered as the most efficient agents in therapeutic strategies. The benefit of an ACEI treatment can be explained by at least three mechanisms: ACEI limit systemic and glomerular capillary hypertension, have an antiproteinuric effect, and retard the development of glomerulosclerosis and tubulointerstitial lesions. These effects have been studied in dogs and cats, and there is now some evidence to support the recommendation of ACEI therapy in dogs and cats with CRF. Nevertheless the prescription of ACEI in such patients should take into account the potential influence of renal impairment on ACEI disposition, and adverse effects on the renal function itself (especially hypotension and acute reductions in glomerular filtration rate). The risk of drug interaction with diuretics, nonsteroidal anti-inflammatory drugs and anesthetics, should not be overestimated. Furthermore, hypotension may occur in patients on a low sodium diet.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15500563/