Peer-reviewed veterinary case report
Anti-endotoxin treatment lowers death in dogs with parvovirus
By WESSELS, B. C. & GAFFIN, S. L.·Published in Journal of Small Animal Practice·1986·View original on Crossref →
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Original publication title: Anti‐endotoxin immunotherapy for canine parvovirus endotoxaemia
- Species:
- dog
Plain-English summary
A group of dogs with severe parvovirus infection received a special treatment called equine anti-endotoxin hyperimmune plasma, in addition to standard care. This treatment helped reduce the death rate significantly compared to dogs that only received conventional therapy. Dogs treated with the anti-endotoxin plasma also spent less time in the hospital, recovering faster than those who did not receive it. This suggests that adding this specific therapy could improve outcomes for dogs suffering from parvovirus and similar illnesses.
People also search for: dog parvovirus treatment · canine parvovirus recovery time · anti-endotoxin treatment for dogs
Abstract
AbstractThe morbidity and mortality associated with canine parvovirus disease (CPV) is caused, in part, by endotoxin (LPS). Equine anti‐endotoxin hyperimmune plasma (Anti‐LPS) was administered to 89 CPV patients in addition to conventional therapy. In Anti‐LPS treated CPV patients mortality was lower (16‐8 per cent, 15/89) than in controls that received conventional therapy alone (66‐7 per cent, 24/36, P < 0–0005). The hospitalization period of survivors was reduced from 8‐5 ± 4‐0 days (controls) to 5‐2 ± 2‐0 days (Anti‐LPS treated group). These results suggest that an anti‐endotoxin specific therapy should be incorporated into the treatment regimen of CPV, and possibly, other canine enteric disorders, known to produce endotoxaemia.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1748-5827.1986.tb03760.x