Peer-reviewed veterinary case report
Anti-Sdx: a "new" auto-agglutinin related to the Sda blood group.
- Journal:
- Transfusion
- Year:
- 1980
- Authors:
- Marsh, W L et al.
Plain-English summary
This study describes a new type of auto-antibody called anti-Sdx, which can cause red blood cells to clump together and may lead to the destruction of these cells in the body. Researchers found that this antibody is most active at room temperature and works best at a slightly acidic level. They tested over 5,000 samples and found that the antibody reacts with certain red blood cells but not with others, indicating a specific relationship to the Sda blood group. Interestingly, the antibody is affected by substances in human saliva, milk, and urine, particularly from people with a specific blood type. Overall, the findings suggest that this new auto-antibody could be important in understanding certain blood group reactions, but the study does not indicate any direct implications for pets.
Abstract
Two examples of a "new" IgM saline-agglutinating auto-antibody are described. The antibodies bind complement, have the ability to cause in vivo hemolysis, and are most active at room temperature at a pH of about 6.5. Despite tests on more than 5,000 people, no nonreactive cell sample has been found. The reactive antigen is not denatured by neuraminidase, papain, or ficin, and is present on i adult red blood cells. The antibodies appear to be slightly inhibited by human saliva and milk, and more convincingly inhibited by urine from Sd(a+) persons. They are not inhibited by urine from Sd(a-) persons, but are strongly inhibited by guinea pig urine. The serologic characteristics indicate a relationship to the Sda blood group and the auto-antibody has been named antiSdx. Sdx antigen is present on red blood cells from some higher primates and is absent from rabbit, rhesus monkey, dog and sheep cells.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/7355457/