Peer-reviewed veterinary case report
Anti-tumor effect of a histone deacetylase inhibitor on canine malignant melanoma.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2026
- Authors:
- Li, Toshio et al.
- Affiliation:
- Graduate School of Agricultural and Life Sciences · Japan
- Species:
- dog
Abstract
Canine malignant melanoma (CMM) is a highly aggressive tumor with limited treatment options. Histone deacetylase (HDAC) inhibitors have shown promise in cancer therapy by modulating gene expression. In this study, we investigated the anti-tumor effect of an HDAC inhibitor, vorinostat, on CMM cell lines. Vorinostat significantly suppressed cell proliferation through apoptosis and G0/G1 phase cell cycle arrest in vitro. These findings suggest that vorinostat might serve as a potential therapeutic agent for dogs with CMM, providing a basis for further in vivo studies.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41354458/