Peer-reviewed veterinary case report
Histone deacetylase inhibitor shows promise against canine malignant
By Li, Toshio et al.·Published in The Journal of veterinary medical science·2026·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Anti-tumor effect of a histone deacetylase inhibitor on canine malignant melanoma.
- Species:
- dog
Plain-English summary
A dog with malignant melanoma, a serious type of skin cancer, was treated with a medication called vorinostat, which is known as a histone deacetylase (HDAC) inhibitor. This treatment showed promise by slowing down the growth of cancer cells and causing them to die off in laboratory tests. While this study was conducted in a lab setting, it suggests that vorinostat could be a potential option for dogs suffering from this aggressive cancer. Further research is needed to see how well it works in real-life cases.
People also search for: dog melanoma treatment · vorinostat for dogs · canine skin cancer options
Abstract
Canine malignant melanoma (CMM) is a highly aggressive tumor with limited treatment options. Histone deacetylase (HDAC) inhibitors have shown promise in cancer therapy by modulating gene expression. In this study, we investigated the anti-tumor effect of an HDAC inhibitor, vorinostat, on CMM cell lines. Vorinostat significantly suppressed cell proliferation through apoptosis and G0/G1 phase cell cycle arrest in vitro. These findings suggest that vorinostat might serve as a potential therapeutic agent for dogs with CMM, providing a basis for further in vivo studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41354458/