Peer-reviewed veterinary case report
Bevacizumab slows tumor growth in cat mammary cancer model
By Michishita, Masaki et al.·Published in The Journal of veterinary medical science·2016·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma.
- Species:
- cat
Plain-English summary
A cat with mammary cancer was treated with a drug called bevacizumab to see if it could help slow down the tumor's growth. This drug works by blocking the blood supply to the tumor, which can help shrink it. The treatment showed promise by reducing the tumor size, although it didn't stop the cancer cells from multiplying. This suggests that bevacizumab might be a useful option for treating cats with mammary tumors in the future.
People also search for: cat mammary cancer treatment · bevacizumab for cats · feline cancer drug options
Abstract
Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26616000/