Peer-reviewed veterinary case report
Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2016
- Authors:
- Michishita, Masaki et al.
- Affiliation:
- Department of Veterinary Pathology · Japan
- Species:
- cat
Abstract
Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26616000/