Peer-reviewed veterinary case report
How antibody levels protect puppies from canine parvovirus
By Elia, G et al.·Published in Journal of veterinary medicine. B, Infectious diseases and veterinary public health·2005·Department of Animal Health and Well-Being, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Antibody levels and protection to canine parvovirus type 2.
- Species:
- dog
Plain-English summary
A group of 12 puppies with varying levels of maternal antibodies against canine parvovirus (CPV) were tested to see how well these antibodies protected them from infection. The puppies were divided into groups based on their antibody levels and then exposed to the virus. Puppies with high antibody levels (320) showed no signs of infection, while those with lower levels (80 and 160) did become infected, even though those levels are typically thought to be protective. This study highlights that some puppies can still get parvovirus despite having maternal antibodies that are usually considered sufficient for protection.
People also search for: puppy parvovirus symptoms · how to protect puppies from parvovirus · maternal antibodies in puppies
Abstract
The relationship between maternally derived antibody (MDA) levels and protection to canine parvovirus (CPV) infection in pups is reported. Twelve pups with a wide range of haemagglutination inhibiting (HI) titres of MDA to CPV were divided into four groups, with each group balanced for antibody titres. The dogs were inoculated with a field CPV-2b strain and clinical signs, virus shedding and antibody response were assessed. The CPV was not detected in the faeces of dogs with HI titres of 320 at any time. In dogs with HI titres up to 160, active CPV replication after challenge was demonstrated by real-time polymerase chain reaction. The successful infection of dogs with HI titres of 80 and 160 was confirmed by seroconversion, evaluated at day 14 post-infection. These findings demonstrated that CPV infection could also occur in the presence of MDA HI titres (> or =80) usually considered fully protective.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16316392/