Peer-reviewed veterinary case report
Whole parasite vaccine shows promise against canine leishmaniasis
By Giunchetti, Rodolfo Cordeiro et al.·Published in Research in veterinary science·2008·Laborató, Brazil·View original on PubMed →
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Original publication title: Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis.
- Species:
- dog
Plain-English summary
A vaccine made from the whole Leishmania parasite was tested to see if it could help protect dogs from leishmaniasis, a serious disease spread by infected sand flies. The study found that the vaccine triggered a strong immune response in dogs, increasing certain immune cells and antibodies that fight the infection. This suggests that the vaccine could be a safe and effective way to help prevent leishmaniasis in dogs, which is especially important in areas where the disease is common.
People also search for: dog leishmaniasis vaccine · canine leishmaniasis symptoms · how to prevent leishmaniasis in dogs
Abstract
Human visceral leishmaniasis, one of the most important zoonoses, is caused by the protozoa Leishmania chagasi (syn. L. infantum) and is present as a fatal disease common in South America and Europe where dogs and wild canids are the main reservoirs. A vaccine against visceral leishmaniasis would be an important tool in the control of this disease in dogs. Although the current strategies for vaccination against leishmaniasis are based on the use of recombinant antigens, killed vaccines are still attractive in terms of stability of their biochemical composition and antigenicity, cost, and safety. Here we evaluate the immunogenicity of a whole parasite vaccine as a promising candidate against canine leishmaniasis, demonstrated by cellular reactivity, changes in the cellular profile of the peripheral blood and by the differential production of immunoglobulins. Our results showed that immunization elicited mainly a strong cellular reactivity and increase in T-lymphocytes, particularly the subpopulation CD8(+) that would be related to the control of tissue parasitism. In addition, a higher production of anti-Leishmania total IgG, characterized by mixed isotypes profile (IgG1 and IgG2), was demonstrated.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17950391/