Antimicrobial activity of a decapeptide against.

Abstract

The increasing frequency of infections and drug resistance ofhas emerged as significant public health challenges, highlighting the urgent need for new antifungal agents. In this study, a decapeptide AntiCADP was designed, which could effectively inhibit the growth of. AntiCADP killedcells by disrupting the cell membrane, inducing ROS accumulation, damaging mitochondria, and ultimately leading to cellular necrosis. Additionally, AntiCADP inhibited the hyphal morphogenesis and biofilm formation of. AntiCADP could also killcells in the mature biofilm. In a mouse subcutaneous infection model, AntiCADP significantly inhibited the development of abscesses, reducedcell counts within abscesses, and suppressed inflammatory cell infiltration at the infected area. Taken together, AntiCADP has the potential to be an antifungal agent against skin infections caused by.IMPORTANCETo effectively cope with the increasing frequency of infections and drug resistance of, various types of new antimicrobial molecules have been studied. Among these molecules, antimicrobial peptides have attracted great attention. In the present study, we designed a decapeptide AntiCADP, which showed good anti-.activityand. AntiCADP killedcells via multiple modes, including disrupting the cell membrane, inducing ROS accumulation, damaging mitochondria, and inducing cellular necrosis. AntiCADP could also inhibit hyphal morphogenesis and biofilm formation ofand killcells in the mature biofilm. Thus, AntiCADP had the potential against skin infections caused by.