Peer-reviewed veterinary case report
Antioxidant supplements in sick dogs and their effects on recovery
By Hagen, D M et al.·Published in The Journal of small animal practice·2019·VCA Bay Area Veterinary Specialists & Emergency Hospital, United States·View original on PubMed →
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Original publication title: Antioxidant supplementation during illness in dogs: effect on oxidative stress and outcome, an exploratory study.
- Species:
- dog
Plain-English summary
A group of 40 sick dogs in the hospital were given either a combination of antioxidant supplements (including vitamin E) or no supplements for 30 days to see if it would help their health. After the treatment, the dogs that received the supplements had higher vitamin E levels, but there were no significant changes in their overall health scores or survival rates compared to those that didn't get the supplements. This suggests that antioxidant supplementation may not improve outcomes for dogs that are seriously ill.
People also search for: dog illness treatment · antioxidants for sick dogs · vitamin E for dogs health
Abstract
OBJECTIVES: To assess whether combination antioxidant supplementation for 30 days in systemically ill dogs alters antioxidant status, degree of lipid peroxidation, clinical score and survival. MATERIALS AND METHODS: Forty client-owned systemically-ill hospitalised dogs were eligible for inclusion. Dogs were randomised to no supplementation (NS; n=19) or supplementation with N-acetylcysteine/S-adenosylmethionine/silybin and vitamin E (AS; n=20) for 30 days. Clinical score and oxidative biomarkers including glutathione, cysteine, vitamin E, selenium and urine isoprostanes/creatinine (F-IsoPs/Cr) were determined on days 0 and 30. Glutathione, cysteine, vitamin E and urine F-IsoPs/Cr were quantified by high-performance liquid chromatography, and selenium concentrations determined using atomic absorption spectroscopy. RESULTS: Thirty-two dogs completed the study (NS, n=16; AS, n=16). Vitamin E concentrations were significantly greater in the supplemented compared to the non-supplemented group. No other markers of oxidative stress significantly changed with supplementation. There was no difference in Day 30 clinical scores or survival between the two groups. CLINICAL SIGNIFICANCE: In this population of systemically-ill hospitalised dogs, combination antioxidant supplementation did not alter redox state or clinical outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31292973/