Peer-reviewed veterinary case report
Radiation therapy response in cats with nasal lymphoma and cell death
By Fu, Dah-Renn et al.·Published in The Journal of veterinary medical science·2016·Graduate School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Apoptosis and Ki-67 as predictive factors for response to radiation therapy in feline nasal lymphomas.
- Species:
- cat
Plain-English summary
A group of cats with nasal lymphoma, the most common nasal tumor in felines, were treated with radiation therapy to see how well they responded. Researchers found that cats with higher levels of a protein called Ki-67 had better responses to treatment and longer survival times. Specifically, those with a Ki-67 index above 40% had a significant increase in their survival compared to those with lower levels. This study suggests that measuring Ki-67 and apoptosis (cell death) in biopsy samples can help predict how well a cat will respond to radiation therapy for nasal lymphoma.
People also search for: cat nasal lymphoma treatment · radiation therapy for cats · Ki-67 index in cats · feline cancer survival rates
Abstract
Nasal lymphoma is the most common nasal tumor in cats and is generally a solitary and radiosensitive tumor. We retrospectively evaluated the response to radiation and survival time in relation to apoptosis and Ki-67 indices in feline nasal lymphomas treated with radiation therapy. The apoptotic and Ki-67 indices were evaluated with TUNEL and immunohistochemical staining in 30 biopsy tissues that were taken before any treatment. These two indices were compared, and differences between different treatment response groups were analyzed. The correlation between the median survival times (MST) and the indices was estimated using the Kaplan Meier method, and statistical differences between survival curves were analyzed using a log-rank method. With regard to apoptotic index, a statistical difference was observed between the samples taken from cats with complete response and stable disease (1.22% vs. 0.45%; P=0.045). The Ki-67 index in cats with both complete response and partial response was significantly higher than in cats with stable disease (44.4% and 39.6% vs. 16.3%; P<0.001 and P=0.008, respectively). The cats with a high level of apoptosis (>0.9%) nasal lymphoma were not significantly prolonged MSTs (P=0.202), however, high Ki-67-positive (>40%) cats experienced a statistically significant relationship with longer survival time (P=0.015). Our results indicate that spontaneous apoptotic and Ki-67 indices are strong predictors for response to radiation therapy in feline nasal lymphomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27086717/