Peer-reviewed veterinary case report
Vincristine-loaded platelet therapy helps some dogs with immune
By Park, Hyung-Jin et al.·Published in Journal of veterinary science·2015·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia.
- Species:
- dog
Plain-English summary
Three dogs with severe immune-mediated thrombocytopenia (a condition where the immune system attacks platelets) were brought in after not responding to the usual treatment with prednisone. They were given a new therapy using vincristine-loaded platelets, which helped two of the dogs show quick improvement in their symptoms. Unfortunately, the third dog continued to worsen and had to be euthanized due to its poor condition. This case highlights how vincristine-loaded platelet therapy can be effective for dogs struggling with this serious blood disorder.
People also search for: dog immune-mediated thrombocytopenia treatment · vincristine for dogs · dog low platelet count symptoms
Abstract
Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly with improved clinical signs while the third dog with recurrent IMT was euthanized due to its deteriorating condition. This case report describes the efficacy of VLP therapy in refractory IMT patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25269722/