Peer-reviewed veterinary case report
Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia.
- Journal:
- Journal of veterinary science
- Year:
- 2015
- Authors:
- Park, Hyung-Jin et al.
- Affiliation:
- College of Veterinary Medicine · South Korea
- Species:
- dog
Abstract
Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly with improved clinical signs while the third dog with recurrent IMT was euthanized due to its deteriorating condition. This case report describes the efficacy of VLP therapy in refractory IMT patients.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25269722/