Peer-reviewed veterinary case report
Corticosteroid enzyme levels do not predict lymphoma outcome in dogs
By Wiedemann, A L et al.·Published in The Journal of small animal practice·2005·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Assessment of corticosteroid-induced alkaline phosphatase as a prognostic indicator in canine lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with lymphoma were treated with chemotherapy to see how well they responded and how long they stayed in remission. Researchers looked at various factors, including a specific enzyme level (sALP) that can rise with corticosteroid treatment. They found that sALP levels did not help predict how well the dogs would respond to treatment or how long they would stay in remission. Instead, the stage of the lymphoma was more important in determining treatment success.
People also search for: dog lymphoma treatment prognosis · elevated alkaline phosphatase in dogs · canine lymphoma remission duration
Abstract
OBJECTIVES: To examine the incidence of elevated corticosteroid-induced alkaline phosphatase (sALP) in dogs with lymphoma and to determine if sALP is a reliable prognostic indicator in canine lymphoma. METHODS: The medical records of 62 canine lymphoma patients treated with a combination chemotherapy protocol from 1994 to 2003 at the University of Illinois Veterinary Teaching Hospital were examined. Variables assessed with respect to response rate and remission duration included age, bodyweight, sex, breed, World Health Organization stage (I to V), substage (a or b), pretreatment administration of corticosteroid, and serum levels of alkaline phosphatase, sALP and alanine aminotransferase. RESULTS: sALP was not statistically significant with respect to response rate or duration of remission, nor was preinduction glucocorticoid administration. Stage was significant with respect to achieving remission. CLINICAL SIGNIFICANCE: It was found that sALP is not a useful prognostic indicator for response rate and remission duration in dogs with lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15835237/