Peer-reviewed veterinary case report
Vitamin E levels and oxidative stress in dogs with immune anemia
By Pesillo, S Anna et al.·Published in American journal of veterinary research·2004·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Assessment of lipid peroxidation and serum vitamin E concentration in dogs with immune-mediated hemolytic anemia.
- Species:
- dog
Plain-English summary
A group of dogs with immune-mediated hemolytic anemia (IMHA), a condition where the immune system attacks red blood cells, showed higher levels of a harmful substance called malondialdehyde (MDA) and lower levels of vitamin E compared to healthy dogs. This suggests that these dogs are experiencing oxidative stress, meaning their bodies are under more strain than normal. The findings indicate that giving antioxidants, like vitamin E, might help dogs with IMHA, but more research is needed to confirm this.
People also search for: dog immune-mediated hemolytic anemia treatment · vitamin E for dogs with anemia · signs of oxidative stress in dogs
Abstract
OBJECTIVE: To determine plasma malondialdehyde (MDA) and serum vitamin E concentrations in dogs with immune-mediated hemolytic anemia (IMHA) and healthy control dogs. SAMPLE POPULATION: Serum and plasma samples from 36 dogs with IMHA and 40 healthy control dogs. PROCEDURE: Blood samples were collected from all study dogs. Plasma MDA concentrations were measured by use of a commercial colorimetric assay, and serum vitamin E concentrations (alpha-, gamma, and delta-tocopherol concentrations) were measured via high-performance liquid chromatography. RESULTS: Plasma MDA concentrations were significantly higher in the dogs with IMHA than in the control dogs. Compared with control dogs, serum alpha-, gamma-, and &tocopherol concentrations were significantly lower in the IMHA-affected dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated a state of oxidative stress and reduced antioxidant reserve in dogs with IMHA; this finding provides support for further investigation of the potential benefits of antioxidant treatment in dogs with this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15631024/