Peer-reviewed veterinary case report
Assessment of Lymphoid Molecular Clonality in Canine Thymoma.
- Journal:
- Journal of comparative pathology
- Year:
- 2018
- Authors:
- Vessieres, F et al.
- Affiliation:
- Animal Health Trust · United Kingdom
- Species:
- dog
Abstract
The aim of this study was to document the molecular clonality of lymphoid cells in canine thymoma using polymerase chain reaction for antigen receptor rearrangement (PARR). Fifteen formalin-fixed and paraffin wax-embedded samples of canine thymoma were analyzed for T- and B-cell receptor clonality. Two of these 15 cases were excluded from the study due to insufficient DNA concentration. Twelve of the 13 remaining samples (92.3%) showed a polyclonal lymphoid component and in one case the lymphoid component was monoclonal (T-cell clonality). PARR could therefore be a useful tool for differentiating canine thymoma from canine mediastinal lymphoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29422318/