Peer-reviewed veterinary case report
Biomarkers show blood vessel damage in cats with mouth inflammation
By Korkmaz, Saadet Gözde & Ok, Mahmut·Published in Veterinary medicine and science·2025·Department of Internal Medicine·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Assessment of Selected Endothelial Damage Biomarkers in the Determination of Endothelial Damage in Cats With Gingivostomatitis.
- Species:
- cat
Plain-English summary
A group of 55 cats with gingivostomatitis, a painful inflammation of the gums and mouth, was studied to understand the damage to blood vessels in their mouths. Most of these cats had viral infections, and they were treated with medication for their condition. While 49 of the cats improved with treatment, unfortunately, 6 did not survive. The study found that certain biomarkers in the blood, specifically ET-1 and SDC-1, were significantly higher in cats with gingivostomatitis, indicating that there is damage to the blood vessels in these cats.
People also search for: cat gingivostomatitis treatment · cat mouth inflammation symptoms · gingivostomatitis in cats recovery
Abstract
BACKGROUND: Feline gingivostomatitis is a chronic disease of domestic cats characterised by inflammatory lesions along the gingiva and oral cavity. OBJECTIVES: The aim of this study was to investigate oral vascular endothelial glycocalyx damage in gingivostomatitis caused by viral infections and other causes in cats using selected biomarkers of endothelial damage. METHODS: The material of this study consisted of 55 cats with gingivostomatitis and 15 healthy cats of different age, breed and sex. A total of 34 of 55 cats with gingivostomatitis had viral infections, whereas the cause of 21 cats could not be determined. Viral diseases were diagnosed by clinical findings and rapid antigen tests. Haemogram analysis was performed from blood samples. Serum endothelin-1 (ET-1), syndecan-1 (SDC-1), myeloperoxidase-ANCA (MPO-ANCA) and interleukin-6 (IL-6) biomarker concentrations were measured using feline-specific commercial ELISA kits. Cats were treated medically for gingivostomatitis. RESULTS: Although 49 cats recovered with the treatment, 6 cats died. There was a significant increase in serum ET-1 and SDC-1 concentrations and no difference in serum MPO-ANCA and IL-6 concentrations in cats with gingivostomatitis. In addition, total leukocyte (WBC), granulocyte (GRA) and monocyte (MON) counts were increased in cats with gingivostomatitis. CONCLUSION: Serum levels of ET-1 and SDC-1, which are biomarkers of vascular endothelial damage, were increased in cats with gingivostomatitis. It was shown that vascular endothelial damage occurs in gingivostomatitis and that the biomarkers ET-1 and SDC-1 can be used to detect this damage and have a reliable diagnostic value.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40719683/