Peer-reviewed veterinary case report
Canine lymphoma relapse linked to cyclophosphamide in CHOP treatment
By Wang, Shang-Lin et al.·Published in Veterinary journal (London, England : 1997)·2016·National Taiwan University Veterinary Hospital·View original on PubMed →
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Original publication title: Assessment of temporal association of relapse of canine multicentric lymphoma with components of the CHOP protocol: Is cyclophosphamide the weakest link?
- Species:
- dog
Plain-English summary
A group of dogs with multicentric lymphoma (a type of cancer) was treated with a common chemotherapy combination called CHOP, which includes cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisolone. While many dogs initially responded well, 41 out of 68 dogs experienced a relapse during treatment, with the relapses happening more often after receiving cyclophosphamide compared to the other drugs. This suggests that switching out cyclophosphamide for a different medication might improve treatment outcomes for dogs with this condition.
People also search for: dog lymphoma treatment options · canine cancer chemotherapy side effects · why does my dog keep relapsing lymphoma
Abstract
Combination chemotherapy, using cyclophosphamide, hydroxydaunorubicin, vincristine and prednisolone (CHOP), is the most commonly used treatment for canine lymphoma. Most affected dogs respond during the initial stages of chemotherapy, but many relapse. The aim of this study was to evaluate the relationship between the use of specific chemotherapy drugs and clinical relapse, using the modified Madison-Wisconsin, 25 week chemotherapy protocol. Forty-one of 68 dogs affected with multicentric lymphoma relapsed during the treatment period. Relapse occurred more frequently after the administration of cyclophosphamide (n = 24; P < 0.01), compared with vincristine (n = 9) or doxorubicin (n = 5). Therefore, the therapeutic outcome of traditional CHOP-based chemotherapy might be improved by replacing cyclophosphamide with other cytotoxic drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27240922/