Peer-reviewed veterinary case report
Does oral afoxolaner kill sandflies on dogs?
By Perier, Nadège et al.·Published in Parasite (Paris, France)·2019·Boehringer Ingelheim Animal Health, France·View original on PubMed →
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Original publication title: Assessment of the insecticidal activity of oral afoxolaner against Phlebotomus perniciosus in dogs.
- Species:
- dog
Plain-English summary
Twelve healthy dogs were tested to see how well a medication called afoxolaner (NexGard) could kill sandflies, which can spread diseases. The dogs were given the medication and then exposed to sandflies at different times over a month. The results showed that afoxolaner was very effective, killing nearly all the sandflies within 48 hours after exposure. This means that giving afoxolaner to dogs can help protect them from these harmful insects for at least a month after just one dose.
People also search for: dog sandfly prevention · NexGard for dogs · how to protect dogs from sandflies
Abstract
Twelve healthy dogs were included in this laboratory efficacy study. Six dogs were randomly allocated based on body weight to an untreated control group and six to an afoxolaner (NexGard) treated group. In the treatment group, afoxolaner was administered orally on Day 0 in accordance with label instructions. On Days 1, 14 and 28, each dog was exposed to 60 unfed female and 10 male Phlebotomus perniciosus sandflies for 1 h. At the end of each exposure period, sandflies were counted and assessed for viability and feeding status. There was no statistical difference in mortality (0.0-5.4%), nor in feeding proportion (61.6-78%) between the control and the treated groups at all 1-h post-exposure assessments. After collection, live fed and unfed sandflies were kept for viability assessments at 48 and 72 h post-exposure. In the untreated control group, the average percentages of live, fed, female sandflies after exposure, on Days 1, 14 and 28, ranged from 51% to 74% at 48 h and from 46% to 57% at 72 h, demonstrating model robustness over the 28 days of the study. Significantly fewer live fed sandflies were recorded for the afoxolaner treated group (p < 0.01). The insecticidal efficacy was 100%, 95.9% and 75.2% at 48 h post Days 1, 14 and 28 exposures, respectively, and 100%, 100% and 86.3% at 72 h post Days 1, 14, and 28 exposures, respectively. A single administration of oral afoxolaner (NexGard) to dogs significantly killed P. perniciosus sandflies 48 and 72 h after blood feeding for 1 month.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31687926/