Peer-reviewed veterinary case report
Dog with unexplained anemia had red blood cell protein changes
By Black, Victoria L et al.·Published in Veterinary clinical pathology·2018·Bristol Veterinary School, United Kingdom·View original on PubMed →
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Original publication title: Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia.
- Species:
- dog
Plain-English summary
A 7-year-old female Jack Russell Terrier was brought to the vet because she was often lethargic and had unexplained anemia, which means her red blood cells were breaking down too quickly. Tests suggested that she might have a hereditary issue affecting her red blood cell membranes. Further analysis showed changes in specific proteins that are important for red blood cell function, similar to a condition seen in humans called hereditary spherocytosis. Unfortunately, the study did not mention specific treatments or outcomes for this dog.
People also search for: dog lethargy causes · Jack Russell Terrier anemia treatment · hereditary spherocytosis in dogs
Abstract
A 7-year-old female neutered Jack Russell Terrier was presented to Langford Vets, the University of Bristol, with a history of chronic intermittent lethargy. Investigations and clinical course were compatible with hereditary hemolysis due to a red blood cell membrane defect. Proteomics was used to explore protein alterations in the presence of a hypothesized red blood cell membrane protein deficiency. Proteomic analysis revealed downregulation of the band 3, and alpha- and beta-adducin proteins, and alterations in the red blood cell proteome consistent with previous reports of changes due to the presence of reticulocytosis and ongoing hemolysis. The spectrum of protein alterations identified in the affected dog may be homologous to a band 3 protein deficiency secondary to hereditary spherocytosis, as described in people.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30024644/