Peer-reviewed veterinary case report
Link Between Severe Gum Disease and Kidney Disease in Dogs
By Glickman, Lawrence T et al.·Published in Preventive veterinary medicine·2011·Department of Emergency Medicine, United States·View original on PubMed →
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Original publication title: Association between chronic azotemic kidney disease and the severity of periodontal disease in dogs.
- Species:
- dog
Plain-English summary
A study found that dogs with more severe gum disease (periodontal disease) are at a higher risk of developing chronic kidney disease (CKD). The research looked at over 164,000 dogs and showed that as the severity of gum disease increased, so did the chances of having kidney problems. For example, dogs with stage 3 or 4 gum disease were 2.7 times more likely to have CKD compared to dogs without gum disease. This suggests that keeping your dog's teeth healthy might help protect their kidneys. Regular dental care could be important for your dog's overall health.
People also search for: dog gum disease symptoms · dog kidney disease signs · how to prevent periodontal disease in dogs
Abstract
Naturally occurring periodontal disease affects >75% of dogs and has been associated with cardiac lesions and presumptive endocarditis. However, the relationships between periodontal disease and chronic kidney disease (CKD) in dogs have not been studied. In a retrospective longitudinal study the incidence of azotemic CKD was compared between a cohort of 164,706 dogs with periodontal disease and a cohort of age-matched dogs with no periodontal disease from a national primary care practice. These dogs contributed 415,971 dog-years of follow-up from 2002 to 2008. Hazard ratios and 95% confidence intervals from Cox regression were used to compare the incidence of azotemic CKD in dogs with stage 1, 2, or 3/4 periodontal disease to dogs with no periodontal disease. The hazard ratio for azotemic CKD increased with increasing severity of periodontal disease (stage 1 hazard ratio=1.8, 95% confidence interval: 1.6, 2.1; stage 2 hazard ratio=2.0, 95% confidence interval: 1.7, 2.3; stage 3/4 hazard ratio=2.7, 95% confidence interval: 2.3, 3.0; P(trend)=<0.0001) after adjustment for age, gender, neuter status, breed, body weight, number of hospital visits, and dental procedures. Increasing severity of periodontal disease was also associated with serum creatinine >1.4 mg/dl and blood urea nitrogen >36 mg/dl, independent of a veterinarian's clinical diagnosis of CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21345505/