Peer-reviewed veterinary case report
Urine biomarker linked to heart valve disease in dogs
By Crosara, Serena et al.·Published in Research in veterinary science·2024·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: Association between echocardiographic indexes and urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in dogs with myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of 77 dogs with myxomatous mitral valve disease (MMVD), a common heart condition, were tested for kidney damage using a urine marker called uNGAL. The study found that certain heart measurements, like left atrial stroke volume and tricuspid regurgitation, were linked to higher levels of uNGAL, indicating a risk for kidney problems. This means that monitoring these heart parameters could help veterinarians identify dogs with MMVD who might be at greater risk for kidney damage. Early detection could lead to better management and treatment options for affected dogs.
People also search for: dog heart disease kidney damage · myxomatous mitral valve disease treatment · elevated uNGAL in dogs
Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of tubular damage, and its elevation has been described in human and canine cardiorenal syndrome. The aim was to evaluate the association between echocardiographic indexes and urine NGAL (uNGAL) and uNGAL normalized to urine creatinine (uNGALC) in dogs with MMVD. This is a multicentric prospective cross-sectional study. A total of 77 dogs with MMVD at different ACVIM stages were included. All dogs underwent echocardiography, serum chemistry, and urinalysis. Echocardiographic data analyzed were shortening fraction (SF), left ventricular diastolic (LVIDDn) and systolic (LVIDSn) diameters normalized for body weight, left atrium to aortic root ratio (LA/Ao), maximal (LAV) and minimal (LAV) left atrial volumes, LA stroke volume (LASV), early diastolic mitral peak velocity (E), Eto tissue Doppler E' wave (E/E'), aortic (VTI) and mitralic (VTI) velocity time integrals and their ratio (VTI/VTI), and tricuspid regurgitation velocity (TR). In the univariate analysis LASV, TR, LAV, LVIDDn, and VTI/VTIwere independent predictors of increased uNGAL and uNGALC; however, only LASV [(OR: 1.96, 95% CI: 1.16 to 3.31) P = 0.01 for NGAL, and (OR: 2.79, 95% CI: 1.50 to 5.17) P < 0.001 for NGALC] and TR[(OR: 1.73, 95% CI: 1.20-2.51) P = 0.002 for NGAL, and (OR: 1.50, 95% CI: 10.07-2.10) P = 0.015 for NGALC] remained statistically significant in the multivariable analysis. Based on our results, LASV and TRare associated with increased uNGAL and uNGALC. These parameters might detect dogs with MMVD at higher risk of developing kidney damage.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38458044/