Peer-reviewed veterinary case report
Low serum sRAGE linked to worse gut inflammation in dogs
By Cabrera-García, Angela Isabel et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2020·Department for Small Animals, Germany·View original on PubMed →
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Original publication title: Association between serum soluble receptor for advanced glycation end-products (RAGE) deficiency and severity of clinicopathologic evidence of canine chronic inflammatory enteropathy.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with chronic inflammatory enteropathy (CIE), which can cause symptoms like vomiting and diarrhea, had their blood tested for a specific protein called soluble RAGE. The study found that lower levels of this protein were linked to more severe intestinal damage in the dogs. However, the researchers noted that these protein levels did not correlate with the overall severity of the dog's clinical symptoms or other inflammatory markers. This suggests that while there may be a connection between serum sRAGE levels and intestinal health, it doesn't directly reflect how sick the dog feels.
People also search for: dog chronic diarrhea treatment · dog vomiting causes · canine inflammatory bowel disease symptoms
Abstract
Innate immunity plays a central role in the pathogenesis of chronic inflammatory enteropathies (CIE) in dogs, and further evaluation of the innate immune receptor for advanced glycation end-products (RAGE) is warranted. We measured serum concentrations of decoy receptor soluble RAGE (sRAGE) in 102 dogs diagnosed with CIE, and evaluated relationships with clinical disease severity, histologic lesion severity, concentrations of serum C-reactive protein (CRP), and serum and fecal calprotectin, S100A12, and alpha-proteinase inhibitor (αPI). Serum sRAGE levels were not associated with clinical disease activity, serum CRP, serum and fecal αPI, calprotectin, or S100A12 concentrations. Microscopic lesions in the duodenum were more severe in dogs with serum sRAGE concentration ≤ 340 ng/L ( = 0.013). Serum sRAGE levels were weakly and inversely correlated with the severity of lymphoplasmacytic infiltration in the gastric antrum and duodenum, and with crypt dilation and the neutrophilic infiltrate in the duodenum, in univariate analysis (all < 0.05), but none of the correlations remained statistically significant after correction for multiple comparisons. Our study confirms that CIE in dogs is associated with decreased serum sRAGE concentrations, suggesting a dysregulated sRAGE/RAGE axis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32715975/