Peer-reviewed veterinary case report
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
- Journal:
- Journal of neural transmission (Vienna, Austria : 1996)
- Year:
- 2014
- Authors:
- Drinovac, V et al.
- Affiliation:
- Department of Pharmacology
Abstract
The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24420081/