Peer-reviewed veterinary case report
Protein in urine at lymphoma diagnosis linked to dog survival times
By Skinner, Stephanie M et al.·Published in Journal of veterinary internal medicine·2024·Friendship Hospital for Animals, United States·View original on PubMed →
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Original publication title: Association of proteinuria at time of diagnosis with survival times in dogs with lymphoma.
- Species:
- dog
Plain-English summary
A study found that dogs with lymphoma who had protein in their urine (proteinuria) at the time of diagnosis had shorter survival times compared to those without proteinuria. Specifically, dogs with proteinuria survived about 245 days on average, while those without it lived around 335 days. This suggests that the presence of proteinuria could be an important factor for veterinarians to consider when assessing a dog's prognosis after a lymphoma diagnosis. If your dog has been diagnosed with lymphoma and has protein in their urine, it's essential to discuss this with your veterinarian for a better understanding of their condition and treatment options.
People also search for: dog lymphoma prognosis · protein in urine in dogs · dog kidney problems with lymphoma
Abstract
BACKGROUND: Lymphoma has been implicated as a possible cause of proteinuria in dogs. However, information about the potential importance of proteinuria in dogs with lymphoma is limited. HYPOTHESIS: To determine if the presence of proteinuria at diagnosis was associated with median survival times in dogs with lymphoma and if lymphoma stage (I-V) or type (B vs T) were associated with the presence of proteinuria. ANIMALS: Eighty-six client-owned dogs with a new diagnosis of lymphoma between 2008 and 2020. METHODS: This was a retrospective cross-sectional study with dogs divided into proteinuric or nonproteinuric groups based on dipstick urine protein (protein ≥30 mg/dL classified as proteinuric) or a ratio of dipstick protein to urine specific gravity (ratio ≥1.5 classified as proteinuric). Dogs were excluded for: (1) treatment within 2 months with glucocorticoid, anti-neoplastic, or anti-proteinuric therapies, (2) diagnosed hypercortisolism or renal lymphoma, (3) active urine sediment, or (4) urine pH >8. Survival analysis utilized a Kaplan-Meier estimator and log-rank testing. RESULTS: There was a significant difference in median survival between proteinuric and nonproteinuric dogs classified by urine dipstick (245 days [91, 399] vs 335 days [214, 456]; P = .03) or UP : USG (237 days [158, 306] vs 304 days [173, 434]; P = .03). No difference in prevalence of proteinuria was identified between stages (I-V) or types (B and T). CONCLUSIONS AND CLINICAL IMPORTANCE: Proteinuria appears to be negatively associated with survival time in dogs newly diagnosed with lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39001675/